Out of Patients with Matthew Zachary
Out of Patients with Matthew Zachary
Matthew Zachary is the healthcare policy love child of Jon Stewart, Howard Stern, Thomas Paine, Ralph Nader, and Jerry Seinfeld. He has 19 years of receipts to prove it. Editorially independent. Answerable to no one. What started as The Stupid Cancer Show in 2007 became Out of Patients. The first online health podcast in America, predating the medium itself. Zachary survived brain cancer at 21, built the young adult cancer movement from scratch, and spent two decades channeling patient rage into something the system never saw coming. Now he is marching into Washington. Out of Patients goes where the comfortable shows will not. Politics. Healthcare policy. Economics. Institutional accountability. Consumer protection. The forces shaping what 330 million Americans can access, afford, and survive. Battle-scarred patients. Exhausted caregivers. Rare insiders brave enough to name what is killing us. And the occasional elected official about to find out what an organized patient constituency actually looks like. This is the show that started the conversation America is still not ready to finish.
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March 4, 2026

[BONUS] Eczema, Exit, Repeat: Dr. Barbra Paldus

[BONUS] Eczema, Exit, Repeat: Dr. Barbra Paldus
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Dr. Barbara Paldus is the Founder and CEO of CODEX Labs, the sponsor of this episode.

She grew up around Nobel Prize winners, built biotech manufacturing equipment for vaccines and cancer therapeutics, and then sold her company after an 8 year old threatened suicide.

Her son’s severe eczema pushed her into an unregulated $100,000,000,000 skincare market where parents are told to trust labels that nobody verifies. She explains how corticosteroid ladders leave patients with years long withdrawal, why U.S. ingredient oversight lags Europe, and how chemotherapy destroys the same skin and gut barriers seen in inflammatory disease.

The conversation tracks the real stakes behind “clean” marketing: a child’s immune system, hospital infections like MRSA, and patients trying to survive treatment without new damage. She also details the research path from Irish medical manuscripts to microbiome science and why sick populations become the only reliable regulators when policy fails.

RELATED LINKS

Barbara Paldus

Codex Labs

Sekhmet Ventures

Dr Peter Lio

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Related to this Episode

Eczema, Exit, Repeat: The Business Model of Chronic Disease

Barbara Paldus built biotech for a living. Then a serious mental health scare involving her young son forced her to rethink everything. This moment pushed her from manufacturing cancer therapeutics into the $100,000,000,000 skin care industry after …